Although anyone considering using orals (methylated AAS) should be aware of their primary negative effects, I feel compelled to mention them, at least in brief. Anavar, like all methyls, is well known to have a negative effect on both the cardiovascular system (via deterioration of the lipid profile) and hepatic function (methyls are metabolized by the liver and therefore result in varying degrees of liver strain). Fortunately, Anavar is relatively mild in terms of liver toxicity, making this less of a concern compared to many other orals and a non-issue when administered in combination with the proper liver support supplements. On the other hand, its effects on the cardiovascular system are not quite so benign. While a temporary alteration of the lipid profile is not going to cause significant problems, remaining in that state for an extended period of time is a major contributing factor in the development of atherosclerosis, which is a major risk factor for heart attack. Therefore, the regular or long-term use of methyls is discouraged, particularly in the absence of preventative measures.