Reduces the effectiveness of uricosuric drugs, increases the effects of anticoagulants, antiplatelet agents, fibrinolytic agents, ethanol, and the side effects of glucocorticosteroids mineralokortikosteroidov, estrogen; reduces the effectiveness of antihypertensive drugs and diuretics.
The joint reception with others. Primobolan dosage, corticosteroids, ethanol, corticotropin may lead to ulceration and the development of gastro-intestinal bleeding, an increase in the risk of impairment of renal function.
Co-administration with oral anticoagulants, heparin, thrombolytics, antiplatelet, cefoperazone, cefamandole and tsefotetanom increases the risk of bleeding.
It increases the hypoglycemic effect of insulin and oral hypoglycemic drugs (requires recalculation of the dose).
Inductors microsomal oxidation in the liver (phenytoin, ethanol, barbiturates, rifampicin, phenylbutazone, tricyclic antidepressants) increase the production of hydroxylated active metabolites.
Co-administration with sodium valproate causes a disturbance of platelet aggregation.
Increases plasma concentration of nifedipine and verapamil, lithium, drugs, methotrexate.
antacids and cholestyramine reduce the absorption.
Myelotoxic drugs increase the expression gematotoksichnosti drug.
pharmaceutical incompatible with a solution of tramadol.