The Oxandrolone hormone does not carry any estrogenic related side effects. It does not aromatize and cannot lead to gynecomastia or water retention due to increases in estrogen levels. It further carries no progestin related activity, which again supports no estrogenic related side effects. Due to water retention being impossible with this steroid, this will decrease the risk of high blood pressure. Excess water retention can promote high blood pressure. Some steroids that do not aromatize can lead to high blood pressure, such as Trenbolone , but Anavar is rarely associated with this trait.
Oxandrolone is a synthetic anabolic steroid that helps to restore lean muscle mass and increase visceral protein stores. Oxandrolone is the only anabolic steroid approved by the Federal Drug Administration (FDA) for the treatment of cachexia. Oxandrolone has also been found to demonstrate a significant improvement in wound healing over a 12 week period in eight out of eight patients with weight loss and non healing chronic wounds . In another study by Yeh et al. , oxandrolone was found improve appetite and increase weight gain in patients with COPD associated weight loss. No studies to date were found that specifically address the use of this agent in the nursing home population. Oxandrolone is contraindicated for use in patients with prostate or breast cancer and may lead to hirsutism and fluid retention. Oxandrolone should also be used with caution in patients with hepatic disease .
Given the positive impact of corticosteroids and progestational agents on cancer anorexia and cachexia and the fact that many patients with advanced cancer die with, and/or of, inanition, the potential prophylactic use of these agents was evaluated. A double-blind trial was conducted in which patients with newly diagnosed, extensive-stage small-cell lung cancer were randomized to receive megestrol or placebo along with standard chemoradiation therapy. This trial was unable to demonstrate any beneficial effect of megestrol on treatment response, quality of life, or survival.