Oxymetholone metabolism

Because of a suspected association between the drug oxymetholone and abnormal glucose metabolism, we determined immunoreactive insulin (IRI) and plasma glucose during oral glucose tolerance testing in seven patients with aplastic anemia, six of whom received oxymetholone therapy. All patients receiving oxymetholone therapy had abnormal glucose and/or IRI values. This finding was independent of GH, cortisol, and glucagon. In one patient, glucose and IRI levels were normal before oxymetholone but became abnormally elevated after the use of this drug. Furthermore, normal glucose and IRI values were present in the single patient not receiving oxymetholone. Thus, a positive relationship was demonstrated between oxymetholone administration and the presence of glucose intolerance and insulin resistance.

Daily therapy and alternate-day therapy with the attenuated androgen oxymetholone were compared in patients with hereditary angioedema (HAE). Fifteen of 16 patients who experienced at least monthly attacks of HAE without treatment were asymptomatic on administration of 5 mg oxymetholene daily. When 13 of the patients who had been maintained asymptomatically on 5 mg oxymetholone daily were advanced to a treatment schedule of 5 mg every other day, seven attacks occurred during a cummulative 50 mo of therapy. The adverse effects that occurred with daily oxymetholone therapy largely subsided when the patients received alternate-day therapy, while a significant mean rise in C4 protein and function occurred only on daily therapy. Statistically significant mean increases in serum levels of C1INH occurred with daily therapy and were maintained with alternate-day therapy. Clinical benefit can be obtained with a treatment program that does not produce a statistically significant rise in C4 protein or function and does not raise C1INH to the lower limit of normal. The finding that alternate-day therapy diminished the side effects of the drug while affording a substantial reduction in the incidence and severity of attacks indicates the feasibility of this therapeutic approach.

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Finally, an autologous fat transplant involves taking fat from another part of the body and injecting it into the face. Since people with lipoatrophy may have lost a lot of subcutaneous fat, it can be difficult to find enough fat for use in the face. Nonetheless, this process can be effective in restoring facial appearance when done by a skilled plastic surgeon. Only one or two treatments are required initially, but later treatments are required to maintain the benefits. Results last for as short as three months in some people and as long as a year or more in others.

Oxymetholone metabolism

oxymetholone metabolism

Finally, an autologous fat transplant involves taking fat from another part of the body and injecting it into the face. Since people with lipoatrophy may have lost a lot of subcutaneous fat, it can be difficult to find enough fat for use in the face. Nonetheless, this process can be effective in restoring facial appearance when done by a skilled plastic surgeon. Only one or two treatments are required initially, but later treatments are required to maintain the benefits. Results last for as short as three months in some people and as long as a year or more in others.

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